Article
Prevalence of CYP2D6 Genotypes and Predicted Phenotypes in a Cohort of Cambodians at High Risk for Infections with Plasmodium vivax.
The American journal of tropical medicine and hygiene - 1 Aug 2020
Spring Michele D, Lon Chanthap, Sok Somethy, Sea Darapiseth, Wojnarski Mariusz, Chann Soklyda, Kuntawunginn Worachet, Kheang Heng Thay, Nou Samon, Arsanok Montri, Sriwichai Sabaithip, Vanachayangkul Pattaraporn, Lin Jessica T, Manning Jessica E, Jongsakul Krisada, Pichyangkul Sathit, Satharath Prom, Smith Philip L, Dysoley Lek, Saunders David L, Waters Norman C
Abstract excerpt
Clinical failure of primaquine (PQ) has been demonstrated in people with CYP450 2D6 genetic polymorphisms that result in reduced or no enzyme activity. The distribution of CYP2D6 genotypes and predicted phenotypes in the Cambodian population is not well described. Surveys in other Asian countries have shown an approximate 50% prevalence of the reduced activity CYP2D6 allele *10, which could translate into...
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