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Real time PCR detection of common CYP2D6 genetic variants and its application in a Karen population study

15 Nov 2018

Abstract excerpt

BACKGROUND: Plasmodium vivax malaria is characterized by relapses arising from the hypnozoite stages in the liver. The only currently registered drug for radical treatment to prevent relapse is primaquine. Primaquine, a prodrug, requires metabolism through the liver cytochrome CYP2D6 isoenzyme to its active metabolite. Mutations in the CYP2D6 gene may thus affect primaquine efficacy. A SNPs genotyping technique...

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PMID: 30442143
DOI: 10.1186/s12936-018-2579-8

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