Article

Genetic Polymorphism of human CYP2D6 gene coding region from vivax malaria cases in Yunnan Province, China

2020-08-01

Abstract excerpt

<h4>Background: </h4> Primaquine is one of two medications able to effectively eliminate the hypnozoites of P. vivax , and therefore has been recommended by World Health Organization (WHO) as the anti-relapsing drug for the treatment of vivax patients. However, 5-hydroxy-primaquine, the presumed active component, must be generated by CYP2D6 enzyme in human hepatocytes and reduced CYP2D6 enzyme activity caused by g...

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Literature Corpus work: f3e131da-10f5-5bd1-8462-ea6169a1ccbb
DOI: 10.21203/rs.3.rs-19379/v4

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