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Article

Primaquine-derived 5,6-orthoquinone concentrations in urine associated with CYP2D6 genotype-predicted phenotype and blood methemoglobin levels.

Antimicrobial agents and chemotherapy - 5 Aug 2026

Vernandes Mario, Agustine Willy, Fadilah Ihsan, Christian Michael, Rumaseb Angela, Subekti Decy, Louisa Melva, Price Ric N, Thriemer Kamala, Baird J Kevin

Abstract excerpt

Cytochrome P450 isotype 2D6 (CYP2D6) enzyme metabolizes the 8-aminoquinoline primaquine into its active form, 5-hydroxyprimaquine. Highly polymorphic CYP2D6 produces different enzyme activity levels among individuals. This diversity influences the therapeutic efficacy of primaquine in preventing Plasmodium vivax malaria relapses. Urinary 5,6-orthoquinone primaquine concentrations in Indonesian patients treated...

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Identifiers

PMID: 42439801
DOI: 10.1128/aac.00539-26
PMCID: PMC13436372

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