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Vitamin C activates pyruvate dehydrogenase (PDH) targeting the mitochondrial tricarboxylic acid (TCA) cycle in hypoxic KRAS mutant colon cancer.

Theranostics - 1 Jan 2021

Cenigaonandia-Campillo Aiora, Serna-Blasco Roberto, Gómez-Ocabo Laura, Solanes-Casado Sonia, Baños-Herraiz Natalia, Puerto-Nevado Laura Del, Cañas Jose Antonio, Aceñero María Jesús, García-Foncillas Jesús, Aguilera Óscar

Abstract excerpt

Background: In hypoxic tumors, positive feedback between oncogenic KRAS and HIF-1α involves impressive metabolic changes correlating with drug resistance and poor prognosis in colorectal cancer. Up to date, designed KRAS-targeting molecules do not show clear benefits in patient overall survival (POS) so pharmacological modulation of aberrant tricarboxylic acid (TCA) cycle in hypoxic cancer has been proposed as a...

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Identifiers

PMID: 33664850
DOI: 10.7150/thno.51265
PMCID: PMC7914362

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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