Article
Depletion of macrophages slows the early progression of renal injury in obese Dahl salt-sensitive leptin receptor mutant rats.
American journal of physiology. Renal physiology - 1 Jun 2020
Poudel Bibek, Shields Corbin A, Brown Andrea K, Ekperikpe Ubong, Johnson Tyler, Cornelius Denise C, Williams Jan M
Abstract excerpt
Recently, we reported that obese Dahl salt-sensitive (SS) leptin receptor mutant (SSLepRmutant) rats display progressive renal injury. The present study demonstrated that the early development of renal injury in the SSLepRmutant strain is associated with an increase in the renal infiltration of macrophages compared with lean SS rats. We also examined whether depletion of macrophages with clodronate would reduce...
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