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Article

Lipotoxic and inflammatory phenotypes in rats with uncontrolled metabolic syndrome and nephropathy.

American journal of physiology. Renal physiology - 1 Sept 2007

Dominguez Jesus, Wu Pengfei, Packer C Subah, Temm Constance, Kelly Katherine J

Abstract excerpt

Anomalous inflammatory responses triggered by the metabolic syndrome cause renal injury. This discovery links renal lipid accumulation with lipotoxicity to inflammation and may explain the insidious fibrosis and cellular decay characteristic of nephropathy in the metabolic syndrome. However, it is not clear whether control of inflammation protects the kidney independently of lipid accumulation, which is a...

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Identifiers

PMID: 17596532
DOI: 10.1152/ajprenal.00021.2007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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