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Article

Protective effects of Rho kinase inhibitor fasudil on rats with chronic kidney disease.

American journal of physiology. Renal physiology - 1 Jun 2013

Kushiyama Taketoshi, Oda Takashi, Yamamoto Kojiro, Higashi Keishi, Watanabe Atsushi, Takechi Hanako, Uchida Takahiro, Oshima Naoki, Sakurai Yutaka, Miura Soichiro, Kumagai Hiroo

Abstract excerpt

The protective effects of Rho kinase inhibitor fasudil against renal diseases have recently been reported. We compared the therapeutic effects of fasudil on the spontaneously hypercholesterolemic (SHC) rat, a model of chronic kidney disease (CKD) with proteinuria, with those of the angiotensin receptor blocker olmesartan (OL) by paying attention to the proteinuria and the macrophage phenotype. SHC rats were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23552860
DOI: 10.1152/ajprenal.00447.2012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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