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Article

Developmental loss, but not pharmacological suppression, of renal carbonic anhydrase 2 results in pyelonephritis susceptibility.

American journal of physiology. Renal physiology - 1 Jun 2020

Ketz John, Saxena Vijay, Arregui Samuel, Jackson Ashley, Schwartz George J, Yagisawa Takafumi, Fairchild Robert L, Hains David S, Schwaderer Andrew L

Abstract excerpt

Carbonic anhydrase II knockout (Car2-/-) mice have depleted numbers of renal intercalated cells, which are increasingly recognized to be innate immune effectors. We compared pyelonephritis susceptibility following reciprocal renal transplantations between Car2-/- and wild-type mice. We examined the effect of pharmacological CA suppression using acetazolamide in an experimental murine model of urinary tract...

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Identifiers

PMID: 32390512
DOI: 10.1152/ajprenal.00583.2019
PMCID: PMC7311712

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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