Article
A Comprehensive Immune Cell Atlas of Cystic Kidney Disease Reveals the Involvement of Adaptive Immune Cells in Injury-Mediated Cyst Progression in Mice.
Journal of the American Society of Nephrology : JASN - 1 Apr 2022
Song Cheng J, Li Zhang, Ahmed Ummey Khalecha Bintha, Bland Sarah J, Yashchenko Alex, Liu Shanrun, Aloria Ernald J, Lever Jeremie M, Gonzalez Nancy M, Bickel Marisa A, Giles Cory B, Georgescu Constantin, Wren Jonathan D, Lang Mark L, Benveniste Etty N, Harrington Laurie E, Tsiokas Leo, George James F, Jones Kenneth L, Crossman David K, Agarwal Anupam, Mrug Michal, Yoder Bradley K, Hopp Katharina, Zimmerman Kurt A
Abstract excerpt
BACKGROUND: Inducible disruption of cilia-related genes in adult mice results in slowly progressive cystic disease, which can be greatly accelerated by renal injury. METHODS: To identify in an unbiased manner modifier cells that may be influencing the differential rate of cyst growth in injured versus non-injured cilia mutant kidneys at a time of similar cyst severity, we generated a single-cell atlas of cystic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.