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Article

Carbonic anhydrase 2 deficiency leads to increased pyelonephritis susceptibility.

American journal of physiology. Renal physiology - 1 Oct 2014

Hains David S, Chen Xi, Saxena Vijay, Barr-Beare Evan, Flemming Weisi, Easterling Robert, Becknell Brian, Schwartz George J, Schwaderer Andrew L

Abstract excerpt

Carbonic anhydrase 2 regulates acid-base homeostasis, and recent findings have indicated a correlation between cellular control of acid-base status and the innate defense of the kidney. Mice deficient in carbonic anhydrase 2 (Car2(-/-) mice) have metabolic acidosis, impaired urine acidification, and are deficient in normal intercalated cells. The objective of the present study was to evaluate the biological...

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Identifiers

PMID: 25143453
DOI: 10.1152/ajprenal.00344.2014
PMCID: PMC4187042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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