Article

Local proximal tubule complement contributes to maladaptive repair in rhabdomyolysis-induced acute kidney injury and escapes systemic inhibition

2026-06-11

Abstract excerpt

<title>Abstract</title> <p> <bold>Background and hypothesis</bold> : Maladaptive repair drives progression from acute kidney injury (AKI) to chronic kidney disease. Injured proximal tubular cells overexpress complement C3 mRNA, but its functional role is not well understood. We hypothesized that complement proteins produced and active locally within proximal tubules drive maladaptive repair and remain inaccessi...

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Literature Corpus work: b23fc418-d36e-57ac-99a4-8ad1f895c908
DOI: 10.21203/rs.3.rs-9932397/v1

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