Functional characterization of a low-frequency V1937I variant in FASN associated with susceptibility to esophageal squamous cell carcinoma.

doi:10.1007/s00204-020-02738-x

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Article

Functional characterization of a low-frequency V1937I variant in FASN associated with susceptibility to esophageal squamous cell carcinoma.

Archives of toxicology - 1 Jun 2020

Wang Xiaoyang, Tian Jianbo, Zhao Qianyu, Yang Nan, Ying Pingting, Peng Xiating, Zou Danyi, Zhu Ying, Zhong Rong, Gao Ying, Chang Jiang, Miao Xiaoping

Abstract excerpt

Metabolic reprogramming has been regarded as one of the core hallmarks of cancer and increased de novo fatty acid synthesis has been documented in multiple tumors including esophageal squamous cell carcinoma (ESCC). Our previous exome-wide analyses found a Val1937Ile variant (rs17848945) in the 34th exon of fatty acid synthase (FASN) that showed a strong association with the risk of ESCC. In this study, we...

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PMID: 32388819
DOI: 10.1007/s00204-020-02738-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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