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Article

Transcriptomic and cellular analyses of CRISPR/Cas9-mediated edition of FASN show inhibition of aggressive characteristics in breast cancer cells.

Biochemical and biophysical research communications - 20 Aug 2020

Gonzalez-Salinas Fernando, Rojo Rocio, Martinez-Amador Claudia, Herrera-Gamboa Jessica, Trevino Victor

Abstract excerpt

Several genes are significantly mutated in breast cancer but only a small percentage of mutations are well-known to contribute to cancer development. FASN is involved in de novo lipogenesis and the regulation of ERα signaling. However, the effect of genetic mutations affecting FASN in breast cancer has not thoroughly studied. Therefore, we used the CRISPR/Cas9 system to edit the FASN locus in MCF-7 cells and...

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Identifiers

PMID: 32703430
DOI: 10.1016/j.bbrc.2020.05.172

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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