Genome-wide association study of esophageal squamous cell cancer identifies shared and distinct risk variants in African and Chinese populations.

doi:10.1016/j.ajhg.2023.08.007

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Article

Genome-wide association study of esophageal squamous cell cancer identifies shared and distinct risk variants in African and Chinese populations.

American journal of human genetics - 5 Oct 2023

Chen Wenlong Carl, Brandenburg Jean-Tristan, Choudhury Ananyo, Hayat Mahtaab, Sengupta Dhriti, Swiel Yaniv, Babb de Villiers Chantal, Ferndale Lucien, Aldous Colleen, Soo Cassandra C, Lee Sang, Curtis Charles, Newton Rob, Waterboer Tim, Sitas Freddy, Bradshaw Debbie, Abnet Christian C, Ramsay Michele, Parker M Iqbal, Singh Elvira, Lewis Cathryn M, Mathew Christopher G

Abstract excerpt

Esophageal squamous cell carcinoma (ESCC) has a high disease burden in sub-Saharan Africa and has a very poor prognosis. Genome-wide association studies (GWASs) of ESCC in predominantly East Asian populations indicate a substantial genetic contribution to its etiology, but no genome-wide studies have been done in populations of African ancestry. Here, we report a GWAS in 1,686 African individuals with ESCC and...

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Identifiers

PMID: 37673066
DOI: 10.1016/j.ajhg.2023.08.007
PMCID: PMC10577073

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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