Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lipogenic enzyme FASN promotes mutant p53 accumulation and gain-of-function through palmitoylation

19 Feb 2025

Abstract excerpt

The tumor-suppressive function of p53 is frequently disrupted by mutations in cancers. Missense mutant p53 (mutp53) protein often stabilizes and accumulates to high levels in cancers to promote tumorigenesis through the gain-of-function (GOF) mechanism. Currently, the mechanism of mutp53 accumulation and GOF is incompletely understood. Here, we identify the lipogenic enzyme FASN as an important regulator of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Cancer, Lipids, and Metabolism
Share to Cancer-related Molecular Pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39971971
DOI: 10.1038/s41467-025-57099-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lipogenic enzyme FASN promotes mutant p53 accumulation and gain-of-function through palmitoylationPMID 39971971Read ↗

Mutant p53-R280K hijacks SREBP1 to promote fatty acid synthesis and breast cancer progression via FASN.Semantic proximity Read ↗

Recent Advances on Mutant p53: Unveiling Novel Oncogenic Roles, Degradation Pathways, and Therapeutic Interventions.Semantic proximity Read ↗

Mechanistic roles of mutant p53 governing lipid metabolism.Semantic proximity Read ↗

Mutant p53 Gain-of-Function: Role in Cancer Development, Progression, and Therapeutic ApproachesSemantic proximity Read ↗

Gain-of-function mutant p53 in cancer progression and therapySemantic proximity Read ↗

Regulation of p53 stability as a therapeutic strategy for cancer.Semantic proximity Read ↗

An Integrative Pan-Cancer Analysis of FASN in Human TumorsSemantic proximity Read ↗

p53R245W Mutation Fuels Cancer Initiation and Metastases in NASH-driven Liver Tumorigenesis.Semantic proximity Read ↗

Lipidome atlas of p53 mutant variants in pancreatic cancer.Semantic proximity Read ↗

Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis.Semantic proximity Read ↗

FBXL6 degrades phosphorylated p53 to promote tumor growthSemantic proximity Read ↗

Mutant p53 as a Regulator and Target of AutophagySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.