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Immune chromatin reader SP140 regulates microbiota and risk for inflammatory bowel disease

2022-03-30

Abstract excerpt

Inflammatory bowel disease (IBD) is driven by host genetics and environmental factors, including commensal microorganisms. Epigenetics facilitate integration of environmental cues for transcriptional output. However, evidence of epigenetic dysregulation directly causing host-commensal dysbiosis and IBD is lacking. Speckled Protein 140 (SP140) is an immune-restricted chromatin ‘reader’ with homology to Autoimmune R...

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Literature Corpus work
b67eba23-ba4a-594f-95a5-c930452a4824
DOI
10.1101/2022.03.29.486273
Open publication

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Immune chromatin reader SP140 regulates microbiota and risk for inflammatory bowel diseaseDOI 10.1101/2022.03.29.486273
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