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Article

Sp140L functions as a herpesvirus restriction factor suppressing viral transcription and activating interferon-stimulated genes

17 Jun 2025

Abstract excerpt

Herpesviruses, including Epstein-Barr virus (EBV) - a human oncogenic virus and essential trigger of multiple sclerosis - must bypass host DNA-sensing mechanisms to establish lifelong, latent infection. Therefore, herpesviruses encode viral proteins to disrupt key host factors involved in DNA sensing and viral restriction. The first viral latency protein expressed, EBNA-LP, is essential for transformation of...

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PMID: 40526717
DOI: 10.1073/pnas.2426339122

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