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Article

Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Feb 2026

Tong Jingyuan, Wang Di, Song Haoze, Sun Ting, Zhao Yanhong, Gu Wenjing, Lin Lexuan, Zhao Yitong, Liang Yipeng, Jin Xu, Fu Rongfeng, Ju Mankai, Gao Jie, Ma Jinfa, Gao Chengjie, Zhang Anqi, Xiao Zhijian, Jiang Erlie, Yang Renchi, Ma Shihui, Zhang Lei, Shi Lihong

Abstract excerpt

Essential thrombocythemia (ET) includes the JAK2 -, CALR-, and MPL-mutated subtypes, and a triple-negative (TN) ET subtype, which lacks these canonical drivers. How specific driver mutations affect hematopoietic stem cell (HSC) heterogeneity and their relation to ET pathogenesis remain unclear. Here, by using single-cell RNA sequencing (scRNA-seq) combined with driver mutation detection across ET patients, it is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41268701
DOI: 10.1002/advs.202505249
PMCID: PMC12866761

Genes

CALR
CXCR4
JAK2
MPL

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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