Article

Erythroid differentiation intensifies RNA mis-splicing in <i>SF3B1</i> -mutant myelodysplastic syndromes with ring sideroblasts

2023-04-12

Abstract excerpt

Myelodysplastic syndromes with ring sideroblasts (MDS-RS) commonly originate from mutations in the splicing factor SF3B1 ( SF3B1 mt ). SF3B1 mt cause RNA mis-splicing, mechanistically established as the major driver of RS development. However, little is known about RS fate and biology after their initial formation in the human bone marrow. We here achieve isolation of viable RS from patient samples, enabling th...

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Literature Corpus work: e6ae6230-9c1c-52a2-a9b1-bfe353853935
DOI: 10.1101/2023.04.11.536355

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