Erythroid Differentiation Enhances RNA Mis-Splicing in SF3B1-Mutant Myelodysplastic Syndromes with Ring Sideroblasts.

doi:10.1158/0008-5472.CAN-23-3038

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Erythroid Differentiation Enhances RNA Mis-Splicing in SF3B1-Mutant Myelodysplastic Syndromes with Ring Sideroblasts.

Cancer research - 16 Jan 2024

Moura Pedro L, Mortera-Blanco Teresa, Hofman Isabel J, Todisco Gabriele, Kretzschmar Warren W, Björklund Ann-Charlotte, Creignou Maria, Hagemann-Jensen Michael, Ziegenhain Christoph, Cabrerizo Granados David, Barbosa Indira, Walldin Gunilla, Jansson Monika, Ashley Neil, Mead Adam J, Lundin Vanessa, Dimitriou Marios, Yoshizato Tetsuichi, Woll Petter S, Ogawa Seishi, Sandberg Rickard, Jacobsen Sten Eirik W, Hellström-Lindberg Eva

Abstract excerpt

Myelodysplastic syndromes with ring sideroblasts (MDS-RS) commonly develop from hematopoietic stem cells (HSC) bearing mutations in the splicing factor SF3B1 (SF3B1mt). Direct studies into MDS-RS pathobiology have been limited by a lack of model systems that fully recapitulate erythroid biology and RS development and the inability to isolate viable human RS. Here, we combined successful direct RS isolation from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Myelodysplastic Syndromes

Share to Phosphoproteins

Share to RNA

Share to RNA Splicing

Share to RNA Splicing Factors

Share to Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 37921711
DOI: 10.1158/0008-5472.CAN-23-3038
PMCID: PMC10790130

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Erythroid Differentiation Enhances RNA Mis-Splicing in SF3B1-Mutant Myelodysplastic Syndromes with Ring Sideroblasts.PMID 37921711Read ↗

Erythroid differentiation intensifies RNA mis-splicing in <i>SF3B1</i> -mutant myelodysplastic syndromes with ring sideroblastsSemantic proximity Read ↗

Exploring the mechanistic link between SF3B1 mutation and ring sideroblast formation in myelodysplastic syndrome.Semantic proximity Read ↗

The E592K variant of SF3B1 creates unique RNA missplicing and associates with high-risk MDS without ring sideroblasts.Semantic proximity Read ↗

Targeting the EIF2AK1 Signaling Pathway Rescues Red Blood Cell Production in SF3B1 -Mutant Myelodysplastic Syndromes With Ringed SideroblastsSemantic proximity Read ↗

Coordinated missplicing of TMEM14C and ABCB7 causes ring sideroblast formation in SF3B1-mutant myelodysplastic syndrome.Semantic proximity Read ↗

SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes.Semantic proximity Read ↗

SF3B1-initiating mutations in MDS-RSs target lymphomyeloid hematopoietic stem cells.Semantic proximity Read ↗

Somatic Mutation of SF3B1, a Gene Encoding a Core Component of RNA Splicing Machinery, in Myelodysplasia with Ring SideroblastsSemantic proximity Read ↗

Patient-specific MDS-RS iPSCs define the mis-spliced transcript repertoire and chromatin landscape of SF3B1-mutant HSPCs.Semantic proximity Read ↗

SF3B1 deficiency impairs human erythropoiesis via activation of p53 pathway: implications for understanding of ineffective erythropoiesis in MDSSemantic proximity Read ↗

Recent advances in the understanding of myelodysplastic syndromes with ring sideroblasts.Semantic proximity Read ↗

SF3B1 mutation identifies a distinct subset of myelodysplastic syndrome with ring sideroblasts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.