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Article

A cohort analysis of men with a family history of BRCA1/2 and Lynch mutations for prostate cancer.

BMC cancer - 25 Jul 2016

Kerr Lynne, Rewhorn Matthew J, Longmuir Mark, Fraser Sioban, Walsh Shaun, Andrew Nicola, Leung Hing Y

Abstract excerpt

BACKGROUND: Prostate cancer (PC) is a major health concern for men worldwide, with an estimated lifetime risk of ~14 %. A recent comprehensive analysis of mutational processes revealed ageing and mismatch repair as the only altered processes in PC. We wish to test if a cohort of men with inherited risk of mismatch repair defect through BRCA1/2 or Lynch Syndrome mutations represents a target population for...

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Identifiers

PMID: 27456091
DOI: 10.1186/s12885-016-2573-x
PMCID: PMC4960816

Genes

BRCA1
MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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