Article
Deciphering how early life adiposity influences breast cancer risk using Mendelian randomization.
Communications biology - 8 Apr 2022
Vabistsevits Marina, Davey Smith George, Sanderson Eleanor, Richardson Tom G, Lloyd-Lewis Bethan, Richmond Rebecca C
Abstract excerpt
Studies suggest that adiposity in childhood may reduce the risk of breast cancer in later life. The biological mechanism underlying this effect is unclear but is likely to be independent of body size in adulthood. Using a Mendelian randomization framework, we investigate 18 hypothesised mediators of the protective effect of childhood adiposity on later-life breast cancer, including hormonal, reproductive,...
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