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A lifecourse mendelian randomization study highlights the long-term influence of childhood body size on later life heart structure

9 Jun 2022

Abstract excerpt

Children with obesity typically have larger left ventricular heart dimensions during adulthood. However, whether this is due to a persistent effect of adiposity extending into adulthood is challenging to disentangle due to confounding factors throughout the lifecourse. We conducted a multivariable mendelian randomization (MR) study to separate the independent effects of childhood and adult body size on 4 magnetic...

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PMID: 35679339
DOI: 10.1371/journal.pbio.3001656

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