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Article

Leveraging family history data to disentangle time-varying effects on disease risk using lifecourse mendelian randomization.

European journal of epidemiology - 1 Jul 2023

Richardson Tom G, Urquijo Helena, Holmes Michael V, Davey Smith George

Abstract excerpt

Lifecourse Mendelian randomization is a causal inference technique which harnesses genetic variants with time-varying effects to develop insight into the influence of age-dependent lifestyle factors on disease risk. Here, we apply this approach to evaluate whether childhood body size has a direct consequence on 8 major disease endpoints by analysing parental history data from the UK Biobank study.Our findings...

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Identifiers

PMID: 37156976
DOI: 10.1007/s10654-023-01001-8
PMCID: PMC10276123

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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