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Article

Evaluating the direct effects of childhood adiposity on adult systemic metabolism: a multivariable Mendelian randomization analysis.

International journal of epidemiology - 10 Nov 2021

Richardson Tom G, Mykkänen Juha, Pahkala Katja, Ala-Korpela Mika, Bell Joshua A, Taylor Kurt, Viikari Jorma, Lehtimäki Terho, Raitakari Olli, Davey Smith George

Abstract excerpt

BACKGROUND: Individuals who are obese in childhood have an elevated risk of disease in adulthood. However, whether childhood adiposity directly impacts intermediate markers of this risk, independently of adult adiposity, is unclear. In this study, we have simultaneously evaluated the effects of childhood and adulthood body size on 123 systemic molecular biomarkers representing multiple metabolic pathways....

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Share to Adiposity
Share to Body Mass Index

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes, Cardiovascular Risks, and Lipoproteins

Share to Genetic Associations and Epidemiology

Share to Genome-Wide Association Study

Share to Mendelian Randomization Analysis

Share to Pediatric Obesity

Share to Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 33783488
DOI: 10.1093/ije/dyab051
PMCID: PMC8580280

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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