Article

Loss of hepatic Lgr4 and Lgr5 promotes nonalcoholic fatty liver disease

2021-11-22

Abstract excerpt

<h4>Background & Aims</h4> The Rspo-Lgr4/5-Znrf3/Rnf43 module is a master regulator of hepatic Wnt/β-catenin signaling and metabolic zonation, but its impact on nonalcoholic fatty liver disease (NAFLD) remains unclear. We studied whether liver-specific loss of the Wnt/β-catenin modulators Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 4/5 (Lgr4/5) promotes nonalcoholic fatty liver disease (NAFLD). <h4>...

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Literature Corpus work: 113db645-58ad-5bde-ab2b-65ea53d7e33c
DOI: 10.1101/2021.11.22.469602

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