Article
Protection against Western diet-induced obesity and hepatic steatosis in liver fatty acid-binding protein knockout mice.
Hepatology (Baltimore, Md.) - 1 Nov 2006
Newberry Elizabeth P, Xie Yan, Kennedy Susan M, Luo Jianyang, Davidson Nicholas O
Abstract excerpt
Liver fatty acid-binding protein (L-Fabp) regulates murine hepatic fatty acid trafficking in response to fasting. In this study, we show that L-Fabp(-/-) mice fed a high-fat Western diet for up to 18 weeks are less obese and accumulate less hepatic triglyceride than C57BL/6J controls. Paradoxically, both control and L-Fabp(-/-) mice manifested comparable glucose intolerance and insulin resistance when fed a...
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