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Article

Variants in the autophagy-related gene IRGM confer susceptibility to non-alcoholic fatty liver disease by modulating lipophagy.

Journal of hepatology - 1 Dec 2016

Lin Yu-Cheng, Chang Pi-Feng, Lin Hsueh-Fang, Liu Kevin, Chang Mei-Hwei, Ni Yen-Hsuan

Abstract excerpt

BACKGROUND & AIMS: Autophagy has been shown to be crucial in the regulation of the intracellular lipid stores in hepatocytes. We hypothesize that immunity-related GTPase family M (IRGM) gene (an autophagy-related gene) variants confer the susceptibility to non-alcoholic fatty liver disease (NAFLD) development. METHODS: 832 obese children and adolescents aged 6-18years were recruited. NAFLD was determined by liver...

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Source

Identifiers

PMID: 27417217
DOI: 10.1016/j.jhep.2016.06.029

Genes

IRGM
GCKR
PNPLA3

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