Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Whole Genome Expression Analysis in a Mouse Model of Tauopathy Identifies MECP2 as a Possible Regulator of Tau Pathology

17 Mar 2017

Abstract excerpt

Increasing evidence suggests that hyperphosphorylation and aggregation of microtubule-associated protein tau (MAPT or tau) correlates with the development of cognitive impairment in Alzheimer’s disease (AD) and related tauopathies. While numerous attempts have been made to model AD-relevant tau pathology in various animal models, there has been very limited success for these models to fully recapitulate the...

Topics

Join the communities discussing this publication.

Alzheimer's disease research and treatments
Genetics and Neurodevelopmental Disorders
Mitochondrial Function and Pathology

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 28367114
DOI: 10.3389/fnmol.2017.00069

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Whole Genome Expression Analysis in a Mouse Model of Tauopathy Identifies MECP2 as a Possible Regulator of Tau PathologyPMID 28367114Read ↗

DNA Methylation in Genetic and Sporadic Forms of Neurodegeneration: Lessons from Alzheimer’s, Related Tauopathies and Genetic TauopathiesSemantic proximity Read ↗

DNA Methylation in Genetic and Sporadic Forms of Neurodegeneration: Lessons From Alzheimers, Related Tauopathies and Genetic TauopathiesSemantic proximity Read ↗

A Genome-wide Gene-Expression Analysis and Database in Transgenic Mice during Development of Amyloid or Tau PathologySemantic proximity Read ↗

Methylomic signatures of tau and amyloid-beta in transgenic mouse models of Alzheimer’s disease neuropathologySemantic proximity Read ↗

Computational and functional prioritization identifies genes that rescue behavior and reduce tau protein in fly and human cell models of Alzheimer disease.Semantic proximity Read ↗

The Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and Therapy.Semantic proximity Read ↗

Expression of non-neuronal Tau in humans and miceSemantic proximity Read ↗

Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylationSemantic proximity Read ↗

Onset of hippocampal network aberration and memory deficits in P301S tau mice are associated with an early gene signatureSemantic proximity Read ↗

Altered CpG methylation in sporadic Alzheimer's disease is associated with APP and MAPT dysregulationSemantic proximity Read ↗

Single-cell Spatial Transcriptional Profiling Uncovers Heterogeneous Cellular Responses to Pathogenic Tau in a Mouse Model of NeurodegenerationSemantic proximity Read ↗

Genome-wide analysis of DNA methylation in an APP/PS1 mouse model of Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.