Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

UHRF2 promotes intestinal tumorigenesis through stabilization of TCF4 mediated Wnt/β‐catenin signaling

6 May 2020

Abstract excerpt

Abstract Intestinal tumors mainly originate from transformed crypt stem cells supported by Wnt signaling, which functions through downstream critical factors enriched in the intestinal stem/progenitor compartment. Here, we show Uhrf2 is predominantly expressed in intestinal crypts and adenomas in mice and is transcriptionally regulated by Wnt signaling. Upregulated UHRF2 correlates with poor prognosis in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Digestive system and related health
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32372448
DOI: 10.1002/ijc.33036

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

UHRF2 promotes intestinal tumorigenesis through stabilization of TCF4 mediated Wnt/β‐catenin signalingPMID 32372448Read ↗

UHRF1 expression is upregulated and associated with cellular proliferation in colorectal cancerSemantic proximity Read ↗

Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties.Semantic proximity Read ↗

UHRF1 is a mediator of KRAS driven oncogenesis in lung adenocarcinomaSemantic proximity Read ↗

SHMT2 Drives the Progression of Colorectal Cancer by Regulating UHRF1 ExpressionSemantic proximity Read ↗

Foxf2 in intestinal fibroblasts reduces numbers of Lgr5(+) stem cells and adenoma formation by inhibiting Wnt signaling.Semantic proximity Read ↗

Single Cell Analysis Reveals Multi-faceted miR-375 Regulation of the Intestinal CryptSemantic proximity Read ↗

UHRF1 Drives Hepatocellular Carcinoma Progression via Epigenetic Repression of SFMBT2Semantic proximity Read ↗

Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomasSemantic proximity Read ↗

Multiple roles and regulatory mechanisms of the transcription factor HNF4 in the intestineSemantic proximity Read ↗

FUBP1 Promotes Colorectal Cancer Stemness and Metastasis via DVL1-Mediated Activation of Wnt/β-Catenin SignalingSemantic proximity Read ↗

Epigenetic factors coordinate intestinal developmentSemantic proximity Read ↗

NHERF1/EBP50 Suppresses Wnt-β-Catenin Pathway-Driven Intestinal Neoplasia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.