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Article

UHRF1 expression is upregulated and associated with cellular proliferation in colorectal cancer

27 Sept 2012

Abstract excerpt

Ubiquitin-like with PHD and ring-finger domain 1 (UHRF1) binds to methylated promoters of a number of tumor-suppressor genes, including p16INK4A and p14ARF, by forming complexes with DNA methyltransferases and HDAC1, resulting in the induction of carcinogenesis. Altered UHRF1 expression has been demonstrated in various types of cancers. Previous reports indicate that UHRF1 expression is regulated by E2F-1...

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PMID: 23023523
DOI: 10.3892/or.2012.2064

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