Article

Interaction between long-range chromatin regulators <i>Nipbl</i> & <i>Isl1</i> synergistically drives heart defects in mice

2025-05-19

Abstract excerpt

<h4>ABSTRACT</h4> Congenital heart defects (CHDs) are frequently observed in the most common form of Cornelia de Lange Syndrome (CdLS), which is caused by haploinsufficiency for NIPBL , a gene involved in chromatin looping and cis-regulatory control of gene expression. Here, we surveyed cardiac defects in mice made Nipbl -haploinsufficient in the second heart field using two Cre drivers: Mef2c-Cre and Isl1-Cr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a15b37f7-98c8-5e55-b9bd-6c03641aa018
DOI: 10.1101/2025.05.15.654123

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Interaction between long-range chromatin regulators <i>Nipbl</i> & <i>Isl1</i> synergistically drives heart defects in miceDOI 10.1101/2025.05.15.654123Read

Multifactorial origins of heart and gut defects in nipbl-deficient zebrafish, a model of Cornelia de Lange Syndrome.Semantic proximity Read

Gastrulation-stage gene expression in <i>Nipbl</i> <sup>+/-</sup> mouse embryos foreshadows the development of syndromic birth defectsSemantic proximity Read

Fate of developmental mechanisms of myocardial plasticity in the postnatal heartSemantic proximity Read

CHARGE syndrome-associated CHD7 acts at ISL1-regulated enhancers to modulate second heart field gene expressionSemantic proximity Read

Transcription factor ISL1 is essential for pacemaker development and functionSemantic proximity Read

Spotlight on Isl1: A Key Player in Cardiovascular Development and DiseasesSemantic proximity Read

NIPBL+/- haploinsufficiency reveals a constellation of transcriptome disruptions in the pluripotent and cardiac states.Semantic proximity Read

Multiple organ system defects and transcriptional dysregulation in the Nipbl(+/-) mouse, a model of Cornelia de Lange Syndrome.Semantic proximity Read

Gastrulation-stage gene expression in Nipbl+/- mouse embryos foreshadows the development of syndromic birth defects.Semantic proximity Read

The effect of Nipped-B-Like (Nipbl) haploinsufficiency on genome-wide cohesin binding and target gene expression: modeling Cornelia de Lange SyndromeSemantic proximity Read

Nipbl and mediator cooperatively regulate gene expression to control limb development.Semantic proximity Read

Disruption of spatiotemporal hypoxic signaling causes congenital heart disease in miceSemantic proximity Read