Article

Ghrelin and relamorelin alleviate hypoglycaemia in humanised mice with congenital hyperinsulinism

2025-10-02

Abstract excerpt

<h4>ABSTRACT</h4> K ATP -channel related hyperinsulinism (K ATP HI) is a genetic disorder of the pancreatic beta cells, manifesting as life-threatening hypoglycaemia in neonates due to dysregulated insulin secretion. Management of the severe diffuse form of K ATP HI currently lacks treatment options, as the first-line therapy octreotide is often insufficiently effective, necessitating radical pancreatectomy in...

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Literature Corpus work: d514fc55-4568-5110-8179-bda91e20956e
DOI: 10.1101/2025.10.02.680116

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