Article
Meta-analysis and functional effects of the SLC30A8 rs13266634 polymorphism on isolated human pancreatic islets.
Molecular genetics and metabolism - 1 May 2010
Cauchi Stéphane, Del Guerra Silvia, Choquet Hélène, D'Aleo Valentina, Groves Christopher J, Lupi Roberto, McCarthy Mark I, Froguel Philippe, Marchetti Piero
Abstract excerpt
BACKGROUND: The C-allele of rs13266634 located in SLC30A8 (ZNT8) has been strongly associated with decreased insulin release and with type 2 diabetes (T2D) susceptibility in some but not all studies. To shed further light on this issue, we performed a meta-analysis of the association between rs13266634 and T2D in different ethnic groups and assessed the relationships between SLC30A8 genotypes and some properties...
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