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Human islet expression levels of Prostaglandin E <sub>2</sub> synthetic enzymes, but not prostaglandin EP3 receptor, are positively correlated with markers of β-cell function and mass in non-diabetic obesity

2021-02-05

Abstract excerpt

Elevated islet production of prostaglandin E 2 (PGE 2 ), an arachidonic acid metabolite, and expression of Prostaglandin E 2 Receptor subtype EP3 (EP3) are well-known contributors to the β-cell dysfunction of type 2 diabetes (T2D). Yet, many of the same pathophysiological conditions exist in obesity, and little is known about how the PGE 2 production and signaling pathway influences non-diabetic beta-cell func...

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Literature Corpus work
ea024ce8-d65e-5a92-bad6-88e17e309513
DOI
10.1101/2021.02.03.429205
Open publication

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Human islet expression levels of Prostaglandin E <sub>2</sub> synthetic enzymes, but not prostaglandin EP3 receptor, are positively correlated with markers of β-cell function and mass in non-diabetic obesityDOI 10.1101/2021.02.03.429205
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