Article

Polycystin-2 is cardioprotective against myocardial infarction by regulating the calcium-mediated ER stress response

2025-08-07

Abstract excerpt

<h4>Background</h4> Patients with autosomal polycystic kidney disease (ADPKD) have an increased risk and worsened outcomes for acute myocardial infarction (AMI), but the mechanism behind this is unknown. Polycystin 2 (PC2), the protein encoded by one of the two main genes mutated in ADPKD, is a calcium-permeant channel ubiquitously expressed; however, its role in cardiomyocytes remains poorly understood. One hall...

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Literature Corpus work: a2be1622-b5f2-5883-a7f5-13522d0eb6e1
DOI: 10.1101/2025.08.05.668747

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