Article
Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum.
The Journal of biological chemistry - 4 Mar 2005
Kaliman Perla, Catalucci Daniele, Lam Jason T, Kondo Richard, Gutiérrez José Carlos Paz, Reddy Sita, Palacín Manuel, Zorzano Antonio, Chien Kenneth R, Ruiz-Lozano Pilar
Abstract excerpt
Myotonic dystrophy (DM) is caused by a CTG expansion in the 3'-untranslated region of a protein kinase gene (DMPK). Cardiovascular disease is one of the most prevalent causes of death in DM patients. Electrophysiological studies in cardiac muscles from DM patients and from DMPK(-/-) mice suggested that DMPK is critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction...
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