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Article

TALPID3 and ANKRD26 selectively orchestrate FBF1 localization and cilia gating.

Nature communications - 4 May 2020

Yan Hao, Chen Chuan, Chen Huicheng, Hong Hui, Huang Yan, Ling Kun, Hu Jinghua, Wei Qing

Abstract excerpt

Transition fibers (TFs) regulate cilia gating and make the primary cilium a distinct functional entity. However, molecular insights into the biogenesis of a functional cilia gate remain elusive. In a forward genetic screen in Caenorhabditis elegans, we uncover that TALP-3, a homolog of the Joubert syndrome protein TALPID3, is a TF-associated component. Genetic analysis reveals that TALP-3 coordinates with...

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PMID: 32366837
DOI: 10.1038/s41467-020-16042-w
PMCID: PMC7198521

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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