Article
The ciliopathy-associated CPLANE proteins direct basal body recruitment of intraflagellar transport machinery.
Nature genetics - 1 Jun 2016
Toriyama Michinori, Lee Chanjae, Taylor S Paige, Duran Ivan, Cohn Daniel H, Bruel Ange-Line, Tabler Jacqueline M, Drew Kevin, Kelly Marcus R, Kim Sukyoung, Park Tae Joo, Braun Daniela A, Pierquin Ghislaine, Biver Armand, Wagner Kerstin, Malfroot Anne, Panigrahi Inusha, Franco Brunella, Al-Lami Hadeel Adel, Yeung Yvonne, Choi Yeon Ja, Duffourd Yannis, Faivre Laurence, Rivière Jean-Baptiste, Chen Jiang, Liu Karen J, Marcotte Edward M, Hildebrandt Friedhelm, Thauvin-Robinet Christel, Krakow Deborah, Jackson Peter K, Wallingford John B
Abstract excerpt
Cilia use microtubule-based intraflagellar transport (IFT) to organize intercellular signaling. Ciliopathies are a spectrum of human diseases resulting from defects in cilia structure or function. The mechanisms regulating the assembly of ciliary multiprotein complexes and the transport of these complexes to the base of cilia remain largely unknown. Combining proteomics, in vivo imaging and genetic analysis of...
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