Article
An essential role for DYF-11/MIP-T3 in assembling functional intraflagellar transport complexes.
PLoS genetics - 28 Mar 2008
Li Chunmei, Inglis Peter N, Leitch Carmen C, Efimenko Evgeni, Zaghloul Norann A, Mok Calvin A, Davis Erica E, Bialas Nathan J, Healey Michael P, Héon Elise, Zhen Mei, Swoboda Peter, Katsanis Nicholas, Leroux Michel R
Abstract excerpt
MIP-T3 is a human protein found previously to associate with microtubules and the kinesin-interacting neuronal protein DISC1 (Disrupted-in-Schizophrenia 1), but whose cellular function(s) remains unknown. Here we demonstrate that the C. elegans MIP-T3 ortholog DYF-11 is an intraflagellar transport (IFT) protein that plays a critical role in assembling functional kinesin motor-IFT particle complexes. We have...
Topics
- Animals
- Animals, Genetically Modified
- Base Sequence
- Biological Transport, Active
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cilia
- DNA Primers
- DNA, Helminth
- Flagella