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Emerging Roles of the EBF Family of Transcription Factors in Tumor Suppression

9 Dec 2009

Abstract excerpt

Alterations in various developmental pathways are common themes in cancer. The early B-cell factors (EBF) are a family of four highly conserved DNA-binding transcription factors with an atypical zinc-finger and helix-loop-helix motif. They are involved in the differentiation and maturation of several cell lineages including B-progenitor lymphoblasts, neuronal precursors, and osteoblast progenitors. During B-cell...

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PMID: 19996307
DOI: 10.1158/1541-7786.mcr-09-0229

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