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The DNA methylation status of the TERT promoter differs between subtypes of mature B-cell lymphomas

26 Jun 2023

Abstract excerpt

Telomerase reverse transcriptase (TERT) plays a key role in the maintenance of chromosomal ends by adding telomeric repetitions (TTAGGG) and, thus, contributes to the preservation of chromosomal stability [ 1 ]. TERT expression is typically absent in normal somatic tissues. Notable exceptions are, besides spermatogonia, germinal center B-cells [ 2 , 3 ]. In contrast to non-malignant tissues, telomerase activity...

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PMID: 37365157
DOI: 10.1038/s41408-023-00872-0

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