Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Dual Roles of NRF2 in Cancer.

Trends in molecular medicine - 1 Jul 2016

Menegon Silvia, Columbano Amedeo, Giordano Silvia

Abstract excerpt

NRF2 has been traditionally considered as a tumor suppressor because its cytoprotective functions are deemed to be the main cellular defense mechanism against exogenous and endogenous insults, including xenobiotics and oxidative stress. However, several recent studies demonstrate that hyperactivation of the NRF2 pathway creates an environment that favors the survival of normal as well as malignant cells,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents
Share to Drug Discovery
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kelch-Like ECH-Associated Protein 1

Share to MicroRNAs

Share to Molecular Targeted Therapy

Share to NF-E2-Related Factor 2

Share to Oxidative Stress

Source

Identifiers

PMID: 27263465
DOI: 10.1016/j.molmed.2016.05.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Dual Roles of NRF2 in Cancer.PMID 27263465Read ↗

Molecular mechanisms and systemic targeting of NRF2 dysregulation in cancer.Semantic proximity Read ↗

Nrf2: bane or blessing in cancer?Semantic proximity Read ↗

Therapeutic Targeting of the NRF2 Signaling Pathway in Cancer.Semantic proximity Read ↗

NRF-mediated autophagy and UPR: Exploring new avenues to overcome cancer chemo-resistanceSemantic proximity Read ↗

Roles of NRF2 in DNA damage repair.Semantic proximity Read ↗

The Keap1–Nrf2 system in cancers: stress response and anabolic metabolismSemantic proximity Read ↗

Nrf2 is a potential therapeutic target in radioresistance in human cancerSemantic proximity Read ↗

Nuclear Factor Erythroid 2-Related Factor 2 in Regulating Cancer Metabolism.Semantic proximity Read ↗

Nrf2, the master redox switch: the Achilles' heel of ovarian cancer?Semantic proximity Read ↗

Molecular Mechanisms Underlying Hepatocellular Carcinoma Induction by Aberrant NRF2 Activation-Mediated Transcription Networks: Interaction of NRF2-KEAP1 Controls the Fate of Hepatocarcinogenesis.Semantic proximity Read ↗

Natural Nrf2 Inhibitors: A Review of Their Potential for Cancer TreatmentSemantic proximity Read ↗

Nrf2 as a target for cancer chemoprevention.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.