Article
The ancillary N-terminal region of the yeast AP-1 transcription factor Yap8 contributes to its DNA binding specificity.
Nucleic acids research - 4 Jun 2020
Maciaszczyk-Dziubinska Ewa, Reymer Anna, Kumar Nallani Vijay, Białek Wojciech, Mizio Katarzyna, Tamás Markus J, Wysocki Robert
Abstract excerpt
Activator protein 1 (AP-1) is one of the largest families of basic leucine zipper (bZIP) transcription factors in eukaryotic cells. How AP-1 proteins achieve target DNA binding specificity remains elusive. In Saccharomyces cerevisiae, the AP-1-like protein (Yap) family comprises eight members (Yap1 to Yap8) that display distinct genomic target sites despite high sequence homology of their DNA binding bZIP...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.