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Structural determinants of specific DNA-recognition by the THAP zinc finger

9 Feb 2010

Abstract excerpt

Human THAP1 is the prototype of a large family of cellular factors sharing an original THAP zinc-finger motif responsible for DNA binding. Human THAP1 regulates endothelial cell proliferation and G1/S cell-cycle progression, through modulation of pRb/E2F cell-cycle target genes including rrm1. Recently, mutations in THAP1 have been found to cause DYT6 primary torsion dystonia, a human neurological disease. We...

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PMID: 20144952
DOI: 10.1093/nar/gkq053

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