Article
H ferritin knockout mice: a model of hyperferritinemia in the absence of iron overload.
Blood - 1 Aug 2001
Ferreira C, Santambrogio P, Martin M E, Andrieu V, Feldmann G, Hénin D, Beaumont C
Abstract excerpt
Ferritin, the iron-storing molecule, is made by the assembly of various proportions of 2 different H and L subunits into a 24-mer protein shell. These heteropolymers have distinct physicochemical properties, owing to the ferroxidase activity of the H subunit, which is necessary for iron uptake by the ferritin molecule, and the ability of the L subunit to facilitate iron core formation inside the protein shell. It...
Topics
- Alleles
- Anemia, Iron-Deficiency
- Animals
- Disease Models, Animal
- Ferritins
- Homeostasis
- Immunohistochemistry
- Iron Overload
- Iron-Regulatory Proteins
- Iron-Sulfur Proteins
- Mice
- Mice, Knockout
- Protein Subunits
- RNA-Binding Proteins
- Tissue Distribution