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Article

A Mouse Model of Cardiomyopathy Induced by Mutations in the Hemochromatosis HFE Gene.

The Canadian journal of cardiology - 1 Jul 2017

Djemai Haidar, Thomasson Rémi, Trzaskus Yvan, Mougenot Nathalie, Meziani Amira, Toussaint Jean-François, Noirez Philippe, Vitiello Damien

Abstract excerpt

BACKGROUND: The heart is 1 of the organs most affected by hereditary hemochromatosis (HH). The clinical impact of cardiomyopathy in patients with HH requires a particular diagnosis and less invasive treatments. We developed a model of cardiomyopathy in knockout (KO) mice for the high-Fe (HFE) gene and assessed left ventricular (LV) function and structure from 7-20 months. METHODS: Male wild-type (WT) heterozygous...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28558946
DOI: 10.1016/j.cjca.2017.03.006

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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