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Article

Modeling Secondary Iron Overload Cardiomyopathy with Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Cell reports - 14 Jul 2020

Rhee June-Wha, Yi Hyoju, Thomas Dilip, Lam Chi Keung, Belbachir Nadjet, Tian Lei, Qin Xulei, Malisa Jessica, Lau Edward, Paik David T, Kim Youngkyun, Choi Beatrice SeungHye, Sayed Nazish, Sallam Karim, Liao Ronglih, Wu Joseph C

Abstract excerpt

Excessive iron accumulation in the heart causes iron overload cardiomyopathy (IOC), which initially presents as diastolic dysfunction and arrhythmia but progresses to systolic dysfunction and end-stage heart failure when left untreated. However, the mechanisms of iron-related cardiac injury and how iron accumulates in human cardiomyocytes are not well understood. Herein, using human induced pluripotent stem...

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Identifiers

PMID: 32668256
DOI: 10.1016/j.celrep.2020.107886
PMCID: PMC7553857

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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