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Article

Mice lacking mitochondrial ferritin are more sensitive to doxorubicin-mediated cardiotoxicity.

Journal of molecular medicine (Berlin, Germany) - 1 Aug 2014

Maccarinelli Federica, Gammella Elena, Asperti Michela, Regoni Maria, Biasiotto Giorgio, Turco Emilia, Altruda Fiorella, Lonardi Silvia, Cornaghi Laura, Donetti Elena, Recalcati Stefania, Poli Maura, Finazzi Dario, Arosio Paolo, Cairo Gaetano

Abstract excerpt

UNLABELLED: Mitochondrial ferritin is a functional ferritin that localizes in the mitochondria. It is expressed in the testis, heart, brain, and cells with active respiratory activity. Its overexpression in cultured cells protected against oxidative damage and reduced cytosolic iron availability. However, no overt phenotype was described in mice with inactivation of the FtMt gene. Here, we used the doxorubicin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24728422
DOI: 10.1007/s00109-014-1147-0
PMCID: PMC4118045

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